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 “I think this could open up new avenues of research in many ways,” Gilman says. He’d like to see the work expanded to include more variables that are already known to increase depression risk—such as family history, previous episodes of major depression, and social factors. “Really what we want to know is where on the distribution of sadness and mood is the dividing line between a serious depressive episode and nondepression. And are there factors that can push people further from or towards that dividing line?”